5 Bedroom homes for sale & real estate in Defiance, MO

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ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/ adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 105.4+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/ exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s

$7,748,800

5 beds3 baths2,815 sq ft

2275 Highway F, Defiance, MO 63341

37 vaulted ceiling • 1840s built cottage • Catering kitchen

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/ adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 22+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/ exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s bu

$3,450,000

5 beds3 baths2,815 sq ft

2275 Highway F Lot 1, Defiance, MO 63341

Frontage on hwy f • 22+/- acres • 22 acre lot

3D WALKTHROUGH

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Stunning brick and stone ranch-style home sitting on 3 private acres surrounded by mature trees and scenic views! This custom-built home boasts 5 bedrooms, 4 full bathrooms, 3 half bathrooms, and over 6,500 square feet of living space including the finished walkout lower level. The property also features an attached 3 car garage and a detached 52 x 40 foot detached garage with a bonus room. The front door opens to the impressive entry foyer with a gallery staircase and leads to the elegant dining room and stunning great room. The great room boasts a floor-to-ceiling brick fireplace, custom millwork, a wall of windows overlooking the grounds, and French doors that open to the expansive deck.

$1,400,000

5 beds5.5 baths6,521 sq ft

220 Northlind Dr, Defiance, MO 63341

Light filled sunroom • Wet bar • Spa like bathroom

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ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Tucked away on 3 beautiful acres with peaceful lake views, this 5-bedroom, 4.5-bath home offers nearly 3,900 square feet above grade and the perfect blend of character, comfort, and room to spread out. Step inside the impressive two-story foyer, where hardwood floors carry you into a home filled with thoughtful details and inviting spaces. The two-story great room immediately draws you in with soaring vaulted ceilings, a fireplace, and a stunning wall of windows framing the wooded surroundings and lake beyond. At the heart of the home, the spacious kitchen is designed for both everyday living and entertaining with custom cabinetry, stainless steel appliances, a gas cooktop, wall oven, cente

$825,000

5 beds4.5 baths4,557 sq ft

2314 Morel Ln, Wildwood, MO 63038

Lake views • Two-story foyer • Two-story great room

OPEN SAT, 2PM TO 4PM3D WALKTHROUGH

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Welcome to a fresh opportunity in the highly desirable Fieldstone Farms neighborhood of O’Fallon! Thoughtfully designed for comfortable living and effortless entertaining, this spacious two-story home offers the versatility, room to grow, and everyday convenience today’s buyers are looking for. With a NEW ROOF INSTALLED IN 2026, this home delivers an important recent improvement and added peace of mind for its next owners. Step inside to a welcoming main level featuring a dedicated home office with French doors, an inviting dining room, and a generously sized family room anchored by a cozy fireplace. Whether hosting gatherings or enjoying quiet evenings at home, these spaces off

$474,900

5 beds3.5 baths3,771 sq ft

6915 Fieldstone Farms Dr, O Fallon, MO 63368

Koi pond • Community pool • New roof installed

FLOOR PLAN

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
This home does not hold back! Brick front with a covered porch welcomes you in, and inside you get space that actually works for how people live today. Main floor has a private office, a dedicated dining room, and a great room with recessed lighting that flows right into a kitchen built for real cooking and real entertaining. Granite counters, an island, electric cooktop, whirlpool stove, stainless appliances, tiled backsplash, and a walk-in pantry. The hearth room off the kitchen has a gas fireplace, perfect for cozy nights. Nine foot ceilings throughout the main level make everything feel open and bright. Upstairs you'll find a second family room plus four bedrooms. The primary suite is a

$775,000

5 beds4.5 baths4,667 sq ft

221 Oakhurst Cir, O Fallon, MO 63367

Covered porch • Brick front • Private office

VIDEO TOUR

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Welcome to a beautifully refined luxury ranch in The Villages of Wildhorse, ideally located near the heart of the Chesterfield Valley. Thoughtfully renovated and meticulously maintained, this home offers an exceptional blend of sophisticated finishes, comfortable living spaces, and resort-style outdoor living. A gracious entry with wood flooring, a custom front door, sidelights, and crown molding opens to an impressive great room where vaulted ceilings, custom built-ins, a dramatic wood-burning fireplace, and abundant natural light create an inviting focal point. The adjoining atrium brings even more character and light to the heart of the home, while the dining room provides an elegant set

$995,000

5 beds3.5 baths4,852 sq ft

1635 Wildhorse Parkway Dr, Wildwood, MO 63005

Custom cabinetry • Remodeled kitchen • Luxury ranch

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Welcome to your dream home in Augusta! This gorgeous custom-built lake house in the heart of Missouri's wine country is everything you've been waiting for! Nestled in the rolling hills just north of the Missouri River, this luxurious ranch in the Augusta Shores community features over 5,200 square feet of living space on 1.3 acres of picturesque property with direct access to the main lake in Augusta Shores, Hickory Lake. You'll have great curb appeal with a brick and stone exterior, oversized 3-car side-entry garage, and professional landscaping leading to the covered front porch. The foyer opens to the stunning 2-story living room, accented by columns and featuring a floor-to-ceiling ston

$1,150,000

5 beds5.5 baths5,226 sq ft

4412 Arrowhead Ridge Ln, Augusta, MO 63332

Community amenities • Gourmet kitchen • Giant ipe deck

3D WALKTHROUGH

ABOUT THIS HOME
5 Bedroom Homes for Sale in Defiance, MO
Set behind a private tree-lined setting on more than 5 acres, this exceptional custom-built ranch offers a rare combination of refined craftsmanship, expansive living spaces, and resort-style outdoor living. Thoughtfully designed with an unmistakable attention to detail, the home welcomes you with 12' ceilings, 8' interior doors, striking light fixtures, coffered and wood-beamed ceilings, and an abundance of natural light throughout. The heart of the home is a true chef’s kitchen, beautifully appointed with granite countertops, an oversized center island with breakfast bar and farmhouse sink, professional-style gas range with multiple burners, heavy-duty cast-iron grates, integrated g

$1,750,000

5 beds6 baths5,728 sq ft

1950 Diehr Rd, Wentzville, MO 63385

Custom-built ranch • More than 5 acres • 5.26 acre lot

Property at 11090 Stonebridge Ln, Wentzville, MO 63385, 5 beds, 4.5 baths

$1,795,000

5 beds4.5 baths6,025 sq ft

11090 Stonebridge Ln, Wentzville, MO 63385

Property at 2780 Dunvegan Dr, Dardenne Prairie, MO 63368, 5 beds, 3.5 baths

$550,000

5 beds3.5 baths3,618 sq ft

2780 Dunvegan Dr, Dardenne Prairie, MO 63368

Property at 17655 Vintage Oak Dr, Glencoe, MO 63038, 5 beds, 4.5 baths

$950,000

5 beds4.5 baths4,786 sq ft

17655 Vintage Oak Dr, Glencoe, MO 63038

Property at 504 Greengage Timber Dr, O Fallon, MO 63368, 5 beds, 3.5 baths

$1,195,000

5 beds3.5 baths4,366 sq ft

504 Greengage Timber Dr, O Fallon, MO 63368

Property at 5 Dragonstone Ct, Dardenne Prairie, MO 63368, 5 beds, 3.5 baths

$967,500

5 beds3.5 baths3,979 sq ft

5 Dragonstone Ct, Dardenne Prairie, MO 63368

Property at 17643 Wildridge Dr, Wildwood, MO 63005, 5 beds, 4.5 baths

$1,099,000

5 beds4.5 baths5,201 sq ft

17643 Wildridge Dr, Wildwood, MO 63005

Property at 325 Gailin Dr, Lake St Louis, MO 63367, 5 beds, 4.5 baths

$724,900

5 beds4.5 baths3,500 sq ft

325 Gailin Dr, Lake St Louis, MO 63367

Property at 4349 Murdoch Ln, Augusta, MO 63332, 5 beds, 4 baths

$639,000

5 beds4 baths3,220 sq ft

4349 Murdoch Ln, Augusta, MO 63332

Property at 35 TBB Grand Meridien Ct, Wildwood, MO 63005, 5 beds, 3.5 baths

$3,225,000

5 beds3.5 baths4,700 sq ft

35 TBB Grand Meridien Ct, Wildwood, MO 63005

Property at 237 Saint Andrews Dr, Saint Albans, MO 63073, 5 beds, 4.5 baths

$1,179,900

5 beds4.5 baths3,813 sq ft

237 Saint Andrews Dr, Saint Albans, MO 63073

Property at 1042 Wings Rd, Saint Albans, MO 63073, 5 beds, 5.5 baths

$3,995,000

5 beds5.5 baths6,697 sq ft

1042 Wings Rd, Saint Albans, MO 63073

Property at 1 Vera Plan @ Auden Mdw, New Melle, MO 63385, 5 beds, 5.5 baths

$1,334,000

5 beds5.5 baths4,394 sq ft

1 Vera Plan @ Auden Mdw, New Melle, MO 63385

Property at Braxton Plan, Cottleville, MO 63304, 5 beds, 3 baths

$681,900

5 beds3 baths3,546 sq ft

Braxton Plan, Cottleville, MO 63304

Listing provided by Zillow

Based on information submitted to the MLS GRID as of Fri Sep 18 2026. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

5 Bedroom Homes for Sale in Defiance

There are currently 3 5 bedroom homes in Defiance. Some of these homes are "Hot Homes," meaning they're likely to sell quickly. Most homes for sale in Defiance stay on the market for 11 days. This map is refreshed with the newest listings in Defiance every 15 minutes.

In the past month, 1 home has been sold in Defiance. Find your dream home in Defiance using the tools above. Use filters to narrow your search by price, square feet, beds, and baths to find homes that fit your criteria. Our top-rated real estate agents in Defiance are local experts and are ready to answer your questions about properties, neighborhoods, schools, and the newest listings for sale in Defiance. Our Defiance real estate stats and trends will give you more information about home buying and selling trends in Defiance. If you're looking to sell your home in the Defiance area, our listing agents can help you get the best price. Redfin is redefining real estate and the home buying process in Defiance with industry-leading technology, full-service agents, and lower fees that provide a better value for Redfin buyers and sellers.

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