Single Story homes for sale & real estate in Mississippi County, MO

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ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Looking for a newer, move in ready home? How about open concept? This 2 bedroom 1 bath home checks those boxes and is so cozy!! The home sits on a corner lot. The front porch is definitely one that you want to sit on and enjoy the nice weather. The whole home is surrounded with automatic dusk to dawn lighting. Open concept is great for entertaining and this one comes with all appliances including washer and dryer! There is also a detached carport on the property you can move to the driveway if you desire covered parking. So if you are looking for your first home this one is a great starter home!!! Schedule your tour today!!!

$86,500

2 beds1 bath682 sq ft

321 2nd St, East Prairie, MO 63845

Detached carport • Front porch • All appliances

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Beautiful large family home seeking new owners! This home has been completely redone! Including new flooring, new roof, new HVAC, new and updated bathrooms, new fencing, and new outbuilding! So when I say the whole home has been redone, I truly mean the whole home!!! This home has a semi open floor plan with a great flow. There are 4 bedrooms and 2 baths with an office so plenty of space for all your needs! The bathrooms have both been redone, including gorgeous new tile floors and vanity with stone countertops. Tons of cabinets and counter space for anyone who loves to cook! And the backyard is wonderful, being fully fenced on a corner lot with an outbuilding! This home truly has it al

$205,000

4 beds2 baths1,756 sq ft

509 Nelson, East Prairie, MO 63845

New fencing • New hvac • New flooring

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Welcome to this beautifully preserved 1937 home, full of character and smart updates. With 3 bedrooms and 1 fully renovated bathroom, this cozy space makes the most of every square foot—perfect for first-time buyers, downsizers, or anyone looking for low-maintenance living with vintage appeal. Original hardwood floors, recently refinished, run throughout most of the home, adding warmth and timeless charm. The updated kitchen features stylish butcher block counters, includes appliances, and a convenient coffee or serving bar—great for casual mornings or hosting friends. Enjoy peace of mind with updated windows, a new central heat & air system (2021), and a Ring security sys

$109,900

3 beds1 bath1,034 sq ft

901 E Cypress St, Charleston, MO 63834

Updated windows • Ring security system • Corner lot

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
This one does not disappoint!! Looking for a large home, move in ready, and just one that gives you those cozy and inviting home vibes? I have it! This home sits in an great location on a corner lot. This beautiful home host 4 bedrooms and 2 baths. Wonderful layout for a growing family with multiple living spaces, multiple fireplaces, office area, huge laundry room, and the possibility of a 3rd bathroom, you will fall in love quickly! This home has large bedrooms, spacious bathrooms, dining in the kitchen and a separate formal dining, large pantry, and storage gallor. You will also get storage room in the attached garage and a storage building. You have to see this one in person to appr

$275,000

4 beds2 baths2,566 sq ft

445 Margaret Dr, East Prairie, MO 63845

Multiple fireplaces • Office area • Huge laundry room

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Need a home with space or a growing family! This home has that with 5 bedrooms and 2 baths. This home has a wonderful layout! When you enter the door this home immediately feels inviting! You will enter into the living space which has dining and wraps around into the kitchen with a second dining. When it comes to the bedrooms it is a split floor plan as well! The laundry area is extremely large and provides a ton of extra storage. You also have a fenced back yard and a 30 X 30 Shop with central air!! Another bonus is this home has alley access to the shop as well!! This home just needs a little TLC and the little touches you want to make it your own!!

$180,000

5 beds2 baths1,662 sq ft

207 W Olive, East Prairie, MO 63845

Alley access • 30 x 30 shop • Fenced back yard

Property at 200 Margaret Dr, East Prairie, MO 63845, 2 beds, 2 baths

$228,900

2 beds2 baths1,888 sq ft

200 Margaret Dr, East Prairie, MO 63845

Property at 20 & 30 Artic Ln, East Prairie, MO 63845, 3 beds, 1 bath

$175,000

3 beds1 bath1,158 sq ft

20 & 30 Artic Ln, East Prairie, MO 63845

Property at 226 Sandy Ln, East Prairie, MO 63845, 5 beds, 3 baths

$280,000

5 beds3 baths2,610 sq ft

226 Sandy Ln, East Prairie, MO 63845

Property at 815 Gail St, Charleston, MO 63834, 5 beds, 3.5 baths

$275,000

5 beds3.5 baths2,559 sq ft

815 Gail St, Charleston, MO 63834

Property at 908 Millar St, East Prairie, MO 63845, 3 beds, 1 bath

$120,000

3 beds1 bath1,090 sq ft

908 Millar St, East Prairie, MO 63845

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NEW 2 HRS AGO

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Spacious 5 bedroom, 2 bath home sits on 2.0 acres. Offering room to spread out both indoors and out. This home features a large living room with a stone fireplace, a dedicated dining area, and a bright kitchen with ample cabinet storage. The split layout provides flexibility, with several oversized bedrooms. The property includes multiple outbuildings, and a large open yard with plenty of potential. Located in a peaceful rural setting, this home is ideal for buyers seeking affordability, space, and the opportunity to personalize a property to their needs. Selling as-is.

$52,000

5 beds2 baths1,347 sq ft

2371 County Highway 401, Benton, MO 63736

Large open yard • Stone fireplace • 2 acre lot

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Your new opportunity has arrived at a great price! This home needs some work but is great for any investor looking to renovate or rent. Located only 10 mins outside of Charleston and 20 mins from Sikeston. This cute home has 3 bedrooms and two bathrooms! It sets on a quiet corner lot in the town of Diehlstadt. It has a large two car carport with a large privacy fence in the backyard. Ready to invest in this property? Give me a call today!

$61,900

3 beds1 bath1,222 sq ft

188 Swank St, Charleston, MO 63834

Privacy fence • Large carport • Corner lot

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
This beautiful home sits on a full acre outside city limits! This one could be just what you are looking for! Great layout with new paint and beautiful colors throughout. This home has beautiful hardwoods, spacious rooms, large kitchen island, huge laundry room, beautiful primary surrounded by windows, and just a wonderful layout! A beautiful yard that has plenty of space to continue the garden, build a shop, and play ball with friends and family. The home is on county water but a brand new well pump was just installed for the garden. Also there is a second septic and county water hook up from a previous home if you do build a shop to connect to! Make sure and schedule your tour today!

$179,000

3 beds2 baths1,394 sq ft

3780 State Hwy 80, Matthews, MO 63867

Large kitchen island • Brand new well pump • Huge laundry room

$99,900

3 beds1 bath1,056 sq ft

203 Russell Ave, Sikeston, MO 63801

9,147 sq ft lot • Parking • Built 1982

3D WALKTHROUGH

$250,000

3 beds2 baths1,432 sq ft

911 Pine St, Sikeston, MO 63801

0.25 acre lot • 2 garage spots • Built 1997

ABOUT THIS HOME
Single Story Home for sale in Mississippi County, MO:
Welcome to this charming three-bedroom, two-bath brick home that blends comfort and style . Kitchen design has plenty of cabinet space. Primary bedroom with en-suite. Classic brick exterior for a timeless curb appeal. Partially finished basement featuring a wet bar making it ideal for recreation room or family room. Extra outside storage. Large patio perfect for outdoor entertaining. Ample off street parking making it nice for guests. Conveniently located close to nearby schools, parks and shopping. Make this your new home just in time for the holidays ! Schedule your showing today.

$200,000

3 beds2 baths1,384 sq ft

847 Cambridge Dr, Sikeston, MO 63801

0.24 acre lot • 4 parking spots • Built 1973

Property at 451 County Road 1320, Bardwell, KY 42023, 3 beds, 3 baths

$199,900

3 beds3 baths2,552 sq ft

451 County Road 1320, Bardwell, KY 42023

Property at 839 E Kathleen St, Sikeston, MO 63801, 2 beds, 1 bath

$94,900

2 beds1 bath957 sq ft

839 E Kathleen St, Sikeston, MO 63801

Property at 731 Davis St, New Madrid, MO 63869, 3 beds, 1.5 baths

$79,900

3 beds1.5 baths1,800 sq ft

731 Davis St, New Madrid, MO 63869

Property at 728 Noonan Ln, Hickman, KY 42050, 3 beds, 2 baths

$126,400

3 beds2 baths1,910 sq ft

728 Noonan Ln, Hickman, KY 42050

Property at 37 Kyle Dr, Benton, MO 63736, 3 beds, 2 baths

$182,500

3 beds2 baths1,650 sq ft

37 Kyle Dr, Benton, MO 63736

Property at 315 Virginia St, Sikeston, MO 63801, 2 beds, 1 bath

$72,000

2 beds1 bath720 sq ft

315 Virginia St, Sikeston, MO 63801

Property at 1201 Yosemite, Sikeston, MO 63801, 3 beds, 2 baths

$309,900

3 beds2 baths1,800 sq ft

1201 Yosemite, Sikeston, MO 63801

Property at 78 Little John Rd, Sikeston, MO 63801, 3 beds, 2 baths

$74,900

3 beds2 baths1,280 sq ft

78 Little John Rd, Sikeston, MO 63801

Property at 919 Troy Ave, Hickman, KY 42050, 3 beds, 1 bath

$74,900

3 beds1 bath1,770 sq ft

919 Troy Ave, Hickman, KY 42050

Property at 608A State Highway H, Sikeston, MO 63801, 3 beds, 2 baths

$280,000

3 beds2 baths2,009 sq ft

608A State Highway H, Sikeston, MO 63801

Property at 950 Second St, New Madrid, MO 63869, 2 beds, 1 bath

$24,900

2 beds1 bath898 sq ft

950 Second St, New Madrid, MO 63869

Property at 733 Matthews Ave, Sikeston, MO 63801, 2 beds, 1 bath

$74,500

2 beds1 bath1,049 sq ft

733 Matthews Ave, Sikeston, MO 63801

Property at 359 Lap Rollings Rd, Barlow, KY 42024, 4 beds, 3 baths

$314,900

4 beds3 baths2,418 sq ft

359 Lap Rollings Rd, Barlow, KY 42024

Property at 1394 County Road 538, Miner, MO 63801, 3 beds, 2 baths

$224,900

3 beds2 baths1,904 sq ft

1394 County Road 538, Miner, MO 63801

Based on information submitted to the MLS GRID as of Tue Dec 02 2025. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

Single Story Homes for Sale in Mississippi County

There are currently 10 single story homes for sale in Mississippi County at a median listing price of $185K. Some of these homes are "Hot Homes," meaning they're likely to sell quickly. Most homes for sale in Mississippi County stay on the market for 72 days. This map is refreshed with the newest listings in Mississippi County every 15 minutes.

In the past month, 3 homes have been sold in Mississippi County. Find your dream home in Mississippi County using the tools above. Use filters to narrow your search by price, square feet, beds, and baths to find homes that fit your criteria. Our top-rated real estate agents in Mississippi County are local experts and are ready to answer your questions about properties, neighborhoods, schools, and the newest listings for sale in Mississippi County. If you're looking to sell your home in the Mississippi County area, our listing agents can help you get the best price. Redfin is redefining real estate and the home buying process in Mississippi County with industry-leading technology, full-service agents, and lower fees that provide a better value for Redfin buyers and sellers.

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