Wayne County, MO homes for sale & real estate

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ABOUT THIS HOME
Wayne County, MO Homes for Sale
227.2 acre +- farm for sale that is spring fed and has Mark Twain National Forest surrounding it! This property features pasture and a house on one side of the county road and wooded with a pond on the other. This large tract of land would be great for your dream farm or perfect for a hunting club. The peace and tranquility of Eads Creak runs through the back of the property and the pasture is fenced and currently used for running cattle. The house on the property has 3 beds and 1 bath, but plenty of extra room for updates and development. With a little bit of TLC this house could be a home. It is currently being rented and being sold as-is. This farm is the perfect opportunity for farming,

$674,900

3 beds1 bath1,479 sq ft

5754 Wayne 421, Mill Spring, MO 63952

Pond • Wooded • Fenced pasture

ABOUT THIS HOME
Wayne County, MO Homes for Sale
Welcome to S-K Ranch! As you enter the property via a private, charming, tree-lined driveway you'll find 100+/- acres of wooded land rich with established timber. The ranch offers a harmonious blend of open space and serene woodlands, along with a 2,292 sq ft home overlooking a picturesque 5+/- acre lake and includes 3 bedrooms and 3 baths for comfortable living. Animal and equestrian enthusiasts will love the comprehensive combination of board, electric, and barbed wire fencing, along with marked hiking and riding trails. Wildlife abounds; ensuring a memorable natural experience! The bunk house, hay barn (with a loft), grain storage, tack rooms, and horse barns (with open and enclosed st

$875,000

3 beds3 baths2,292 sq ft

858 Wayne RM, St Francois Township, MO 63964

Picturesque lake • Bunk house • Marked hiking trails

ABOUT THIS HOME
Wayne County, MO Homes for Sale
Located at 197 Wayne 340, Piedmont, MO 63957, this single-family residence, promises a unique opportunity to create your ideal living space. HVAC installed in 2022, mini split in basement installed March 2025, roof 2023, new gutters, drains and basement sealed in November 2024, new natural gas water heater and new washer and gas dryer. The interior has new drywall and fresh paint and will need finished. This property holds the potential for a wonderful home. Imagine the possibilities within this residence, ready to be shaped to your vision. This is an address where you can make lasting memories.

$250,000

3 beds3.5 baths3,538 sq ft

197 Wayne 340, Piedmont, MO 63957

0.92 acre lot • 2 garage spots • Built 1969

ABOUT THIS HOME
Wayne County, MO Homes for Sale
Discover you dream farm! This 102 +- acre property boast 60 +- acres of well-maintained, fenced pasture that is currently used for cattle grazing, complete with a couple ponds and Dry Creek running through the property. Across the road you will find 40 +- acres of wooded land, ideal for hunting or simply enjoying nature. Conveniently located near Clearwater Lake which is great for recreation and relaxation. Don't miss out on this beautiful farm on the outskirts of Piedmont!

$349,900

0 beds— baths— sq ft

0 CR 352, Piedmont, MO 63957

Clearwater lake • 102 acre property • Couple ponds

ABOUT THIS HOME
Wayne County, MO Homes for Sale
17± Acre Property with Multiple Spring-Fed Ponds Discover the perfect setting for your dream home or recreational retreat on this beautiful 17-acre (more or less) parcel. Featuring two spring-fed ponds and a third shared pond, this property offers serene water views and a peaceful natural setting. With electric, water, and sewer already on site, it's ready for immediate development. Enjoy nearby outdoor attractions including Sam A. Baker State Park, Clearwater Lake, and Wappapello Lake, with thousands of acres of Mark Twain National Forest just minutes away. Conveniently located only five minutes off Highway 67 and free from any restrictions—this land is ready for your vision.

$149,999

0 beds— baths— sq ft

873 County Road 312, Logan Township, MO 63956

Acre property • Serene water views • 17 acre lot

Property at 0 Highway N Angus Lane 1, Patterson, MO 63956, 3 beds, 2 baths

$1,600,000

3 beds2 baths— sq ft

0 Highway N Angus Lane 1, Patterson, MO 63956

Property at 352 Madison Wayne 9305, Marquand, MO 63655, 3 beds, 2.5 baths

$895,000

3 beds2.5 baths3,600 sq ft

352 Madison Wayne 9305, Marquand, MO 63655

Property at 19203 Wayne Route D, Wappapello, MO 63966, 4 beds, 4 baths

$399,000

4 beds4 baths3,128 sq ft

19203 Wayne Route D, Wappapello, MO 63966

Property at 1095 State Highway 143, Patterson, MO 63956, 4 beds, 2.5 baths

$274,900

4 beds2.5 baths2,645 sq ft

1095 State Highway 143, Patterson, MO 63956

Property at 000 County Road 456, Mill Spring Township, MO 63957

$339,900

0 beds— baths— sq ft

000 County Road 456, Mill Spring Township, MO 63957

Property at 122 Whitney Ln, Piedmont, MO 63957, 3 beds, 1.5 baths

$220,000

3 beds1.5 baths1,400 sq ft

122 Whitney Ln, Piedmont, MO 63957

Property at 1241 S Main St, Piedmont, MO 63957

$47,000

0 beds— baths— sq ft

1241 S Main St, Piedmont, MO 63957

Property at 9 Mattingly, Wappapello, MO 63966

$52,500

0 beds— baths— sq ft

9 Mattingly, Wappapello, MO 63966

Property at 00 North & South of CR 441, Mill Spring, MO 63925

$110,000

0 beds— baths— sq ft

00 North & South of CR 441, Mill Spring, MO 63925

Property at 0 River Lot 7, Mill Spring, MO 63925

$65,000

0 beds— baths— sq ft

0 River Lot 7, Mill Spring, MO 63925

Property at 0 North & South of CR 441, Mill Spring, MO 63925

$199,900

0 beds— baths— sq ft

0 North & South of CR 441, Mill Spring, MO 63925

Property at 0 River Lot 14, Mill Spring, MO 63925

$80,000

0 beds— baths— sq ft

0 River Lot 14, Mill Spring, MO 63925

Property at 0 River Lot 3, Mill Spring, MO 63925

$80,000

0 beds— baths— sq ft

0 River Lot 3, Mill Spring, MO 63925

Property at 0 River Lot 4, Mill Spring, MO 63925

$80,000

0 beds— baths— sq ft

0 River Lot 4, Mill Spring, MO 63925

Property at 0 River Lot 1, Mill Spring, MO 63925

$60,000

0 beds— baths— sq ft

0 River Lot 1, Mill Spring, MO 63925

Property at 0 River Lot 5, Mill Spring, MO 63925

$80,000

0 beds— baths— sq ft

0 River Lot 5, Mill Spring, MO 63925

Property at 900 Private 417-38 Rd, Salem, MO 65560

$24,999

0 beds— baths— sq ft

900 Private 417-38 Rd, Salem, MO 65560

Property at 0 Forest Road 3123, Williamsville, MO 63967

$80,000

0 beds— baths— sq ft

0 Forest Road 3123, Williamsville, MO 63967

Property at 1710 County Road 551, Williamsville, MO 63967

$19,999

0 beds— baths— sq ft

1710 County Road 551, Williamsville, MO 63967

Property at 3 Highway E, Lowndes, MO 63951

$195,000

0 beds— baths— sq ft

3 Highway E, Lowndes, MO 63951

Property at 300 County Rd 453b, Piedmont, MO 63957

$12,999

0 beds— baths— sq ft

300 County Rd 453b, Piedmont, MO 63957

Property at 1 Black River Retreat 1, Piedmont, MO 63957

$6,000

0 beds— baths— sq ft

1 Black River Retreat 1, Piedmont, MO 63957

Property at 4 Turkey Crk, Lowndes, MO 63951

$79,800

0 beds— baths— sq ft

4 Turkey Crk, Lowndes, MO 63951

Property at 214 Wayne 503 B, Lowndes, MO 63951

$349,999

0 beds— baths— sq ft

214 Wayne 503 B, Lowndes, MO 63951

Property at 523 Faith Rd, Wappapello, MO 63967

$115,000

0 beds— baths— sq ft

523 Faith Rd, Wappapello, MO 63967

Property at 406 Durham, Piedmont, MO 63957

$15,000

0 beds— baths— sq ft

406 Durham, Piedmont, MO 63957

Property at 000 County Road 505, Greenville, MO 63944

$5,900

0 beds— baths— sq ft

000 County Road 505, Greenville, MO 63944

Property at 000 Kent Dr, Wappapello, MO 69366

$5,900

0 beds— baths— sq ft

000 Kent Dr, Wappapello, MO 69366

Property at 00 Main, Mill Spring, MO 63952

$7,000

0 beds— baths— sq ft

00 Main, Mill Spring, MO 63952

Property at TBD Forest Dr, Wappapello, MO 63966

$89,500

0 beds— baths— sq ft

TBD Forest Dr, Wappapello, MO 63966

Property at 0 Highway E, Lowndes, MO 63951

$29,500

0 beds— baths— sq ft

0 Highway E, Lowndes, MO 63951

Unknown Last list price

— beds— baths— sq ft

288 Deer Run Acres A, Williamsville, MO 63967

Property at TBD Highway 34, Silva, MO 63964

$503,900

0 beds— baths— sq ft

TBD Highway 34, Silva, MO 63964

Property at 882 Wayne 459, Piedmont, MO 63957

$45,000

0 beds— baths— sq ft

882 Wayne 459, Piedmont, MO 63957

Property at 0000 Madison Wayne 9305 Marquand, Marquand, MO 63655

$425,000

0 beds— baths— sq ft

0000 Madison Wayne 9305 Marquand, Marquand, MO 63655

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Based on information submitted to the MLS GRID as of Tue Jan 06 2026. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

Average home prices near Wayne County, MO

Cities

Counties

Dunklin County homes for sale
$114,950
Shannon County homes for sale
$236,000
Cape Girardeau County homes for sale
$287,300

Wayne County, MO real estate trends

All Home Types trends in Wayne County, MO

Median Sale Price
# of Homes Sold
Median Days on Market

All Home Types

Median Sale Price (All Home Types)

$170,600

+24.8% YoY | Nov 2025

1 year
3 year
5 year

Based on Redfin calculations of home data from MLS and/or public records.

Location

Data

Nov 2025

Growth

% YoY

Wayne County, MO

$170,600

+24.8%

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