Set within thе highlу sοught‐after Mау River Forest neighborhood οf Ρalmetto Bluff, 22 Smilax Vine Road presents a rare opportunity to create a custom Lowcountry retreat on an exceptional 2.21-acre homesite. Tucked away on a quiet cul-de-sac and surrounded by protected maritime forest, the homesite enjoys a remarkable sense of privacy while opening to beautiful views of the 16th fairway of the Jack Nicklaus Signature Golf Course. The generous acreage provides an inspiring canvas for a thoughtfully designed residence, with the golf course setting creating a picturesque backdrop and an opportunity to embrace expansive outdoor living. Surrounded by the distinctive landscape of May River Forest, the homesite captures the essence of Palmetto Bluff-where architecture and nature are thoughtfully intertwined. Life at Palmetto Bluff is defined by an extraordinary connection to nature and an unparalleled collection of amenities. Miles of walking and biking trails wind through forests and along waterways, while the community offers championship golf, equestrian facilities, fitness and wellness experiences, boating and river access, restaurants, shops, and an abundance of outdoor pursuits. From quiet mornings surrounded by nature to afternoons on the river and evenings gathered with family, Palmetto Bluff offers an enduring Lowcountry lifestyle unlike any other. With its combination of 2.21 acres, golf course views, mature natural surroundings, and coveted May River Forest location, 22 Smilax Vine Road represents an exceptional opportunity to create a one-of-a-kind Lowcountry legacy property-one thoughtfully designed for both the beauty of today and the generations to come.
Vacant landProperty Type
2.21 acresLot Size
$993,213Price/Acres
Listed by Bryan Byrne• Palmetto Bluff Real Estate Co
Howard Hanna Allen Tate Lowcountry, (843) 341-3700
Around this home
Schools
K - 12
Preschool & daycare
Pritchardville Elementary
Public PreK-5 • Assigned • 5.2mi
10/10
H. E. McCracken Middle School
Public 6-8 • Assigned • 2.1mi
5/10
May River High
Public 9-12 • Assigned • 4.8mi
9/10
Provided by GreatSchools
Lifestyle
Provided by Walk Score and Local Logic
Property details
Interior
Exterior
Finance
Interior features
Unfurnished
Exterior features
Community pool
Has a view
2.21 (unit not specified) lot area
Utilities
Public water
HOA & community
Community amenities include basketball court, bocce court, marina, boat ramp, clubhouse, dock, dog park, fitness center, garden area, playground, pickleball, pool, RV/boat storage, restaurant, gated/guard service, spa/hot tub, tennis courts, and trails
Electricity and solar
View estimated energy costs and solar savings for this home
Located within the gated May River Forest neighborhood of Palmetto Bluff, 22 Smilax Vine presents a rare opportunity to own one of the few remaining undeveloped homesites on the May River Golf Course. The 2.2 acre property sits at the end of a quiet cul-de-sac on a street with only four homesites and showcases over 325 linear feet on the 8th hole of the Jack Nicklaus signature course. The property is bordered by preserved green space and live oaks, providing tranquility and ultimate privacy, yet is only a short golf cart ride away from the center of Wilson Village and all the club amenities.
RSMLS #399485
Sep 1, 2020
Sold
$455,000
Feb 14, 2020
Listed
$485,000
22 Smilax Vine Road is an expansive 2.2-acre homesite in the May River Forest neighborhood of Palmetto Bluff. This beautiful Lowcountry neighborhood is located just beyond Wilson Village and is home to the May River Golf Course, a par-72 Jack Nicklaus signature course. This coveted homesite is located on a quiet cul-de-sac and is surrounded by protected maritime forest with views of the 16th fairway. With ample space to build a custom home, while maintaining the natural landscape, this property guarantees the ideal spot to enjoy the South Carolina Lowcountry.
Public Records
Aug 1, 2018
Sold
$435,000
Year
Property tax
Land + Additions
Assessment*
2025
$26,017 (+194.7%)
2024
$8,829
2023
$8,829 (+10.0%)
2022
$8,029 (+1.9%)
2021
$7,881 (+7.6%)
2020
$7,323 (+1.5%)
2019
$7,216 (+64.0%)
2018
$4,400 (+9.8%)
2017
$4,005 (+0.8%)
2016
$3,975 (+3.4%)
2015
$3,846 (−1.2%)
2014
$3,893
Public record
Beds
—
Baths
—
Stories
—
Lot width
—
Lot depth
—
Lot size
2.2 Acres
Year renovated
—
Finished Sq. Ft.
—
Unfinished Sq. Ft.
—
Total Sq. Ft.
—
Year built
—
Style
Vacant Land
County
Beaufort County
APN
R614 038 000 1656 0000
Parking Spaces
—
Basement
—
Accessible
—
HOA Dues
—
Garage
—
Features
—
Last updated by owner on Apr 21, 2026.
Climate risks
3/10 Flood Factor
Minimal risk of a flood reaching the building in the next 30 years
3/10 Fire Factor
0.46% chance of being in a wildfire in next 30 years
10/10 Heat Factor
7 days above 106° expected this year, 17 days in 30 years
9/10 Wind Factor
99% chance of strong winds in next 30 years
3/10 Air Factor
2 unhealthy days expected this year, 3 days in 30 years
Provided by First Street
Historical weather
Bluffton, SC • 29910
Average low and high temperatures (°F)
57
37
65
44
73
52
79
61
83
68
88
73
92
76
85
73
84
71
77
60
72
53
61
44
Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
Sun exposure
In this area, properties receive around 9.1 hours in
June and 5.5 hours in December, which is comparable to the
U.S. average for solar exposure.
9.1 hrs
5.5 hrs
JuneDecember
Provided by Shadowmap
Redfin Estimate for 22 Smilax Vine Rd
$2,203,528
$8,528 over list price of $2.20M
Nearby comparable homes
The Redfin Estimate uses 6 recent nearby sales, priced between $1.6M to $2.7M.